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Article

Thermodynamic dissection of a low affinity protein-protein interface involved in human immunodeficiency virus assembly.

The Journal of biological chemistry - 25 Jul 2003

del Alamo Marta, Neira Jose Luis, Mateu Mauricio G

Abstract excerpt

Homo-dimerization of the capsid protein CA of human immunodeficiency virus through its C-terminal domain constitutes an early crucial step in the virion assembly pathway and a potential target for antiviral inhibitors. We have truncated to alanine the 20 amino acid side chains per monomer that participate in intersubunit contacts at the CA dimer interface and analyzed their individual energetic contribution to...

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Source

Identifiers

PMID: 12761222
DOI: 10.1074/jbc.M304466200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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