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Article

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.

Structure (London, England : 1993) - 1 Dec 2005

Cho Sangwoo, Swaminathan Chittoor P, Yang Jianying, Kerzic Melissa C, Guan Rongjin, Kieke Michele C, Kranz David M, Mariuzza Roy A, Sundberg Eric J

Abstract excerpt

Although protein-protein interactions are involved in nearly all cellular processes, general rules for describing affinity and selectivity in protein-protein complexes are lacking, primarily because correlations between changes in protein structure and binding energetics have not been well determined. Here, we establish the structural basis of affinity maturation for a protein-protein interaction system that we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16338406
DOI: 10.1016/j.str.2005.08.015
PMCID: PMC2746401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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