Article
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.
Cell - 13 Dec 2002
Schubert Wolf Dieter, Urbanke Claus, Ziehm Thilo, Beier Viola, Machner Matthias P, Domann Eugen, Wehland Jürgen, Chakraborty Trinad, Heinz Dirk W
Abstract excerpt
Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian cells by inducing its own phagocytosis. The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. We present the crystal structures of the functional domain of InlA alone and in a complex with the...
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