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Article

Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.

The Journal of biological chemistry - 12 Dec 2003

Yang Jianying, Swaminathan Chittoor P, Huang Yuping, Guan Rongjin, Cho Sangwoo, Kieke Michele C, Kranz David M, Mariuzza Roy A, Sundberg Eric J

Abstract excerpt

When two proteins associate they form a molecular interface that is a structural and energetic mosaic. Within such interfaces, individual amino acid residues contribute distinct binding energies to the complex. In combination, these energies are not necessarily additive, and significant positive...

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Identifiers

PMID: 14514664
DOI: 10.1074/jbc.M306848200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14514664-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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