Article
Long-range cooperative binding effects in a T cell receptor variable domain.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006
Moza Beenu, Buonpane Rebecca A, Zhu Penny, Herfst Christine A, Rahman A K M Nur-ur, McCormick John K, Kranz David M, Sundberg Eric J
Abstract excerpt
Although cellular processes depend on protein-protein interactions, our understanding of molecular recognition between proteins remains far from comprehensive. Protein-protein interfaces are structural and energetic mosaics in which a subset of interfacial residues, called hot spots, contributes disproportionately to the affinity of the complex. These hot-spot residues can be further clustered into hot regions....
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