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Article

An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism.

Nature communications - 7 Oct 2016

Huang Bau-Lin, Trofka Anna, Furusawa Aki, Norrie Jacqueline L, Rabinowitz Adam H, Vokes Steven A, Mark Taketo M, Zakany Jozsef, Mackem Susan

Abstract excerpt

The number of phalanges and joints are key features of digit 'identity' and are central to limb functionality and evolutionary adaptation. Prior chick work indicated that digit phalanges and their associated joints arise in a different manner than the more sparsely jointed long bones, and their identity is regulated by differential signalling from adjacent interdigits. Currently, there is no genetic evidence for...

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Identifiers

PMID: 27713395
DOI: 10.1038/ncomms12903
PMCID: PMC5059757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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