Article
A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.
Development (Cambridge, England) - 1 Apr 1996
Davis A P, Capecchi M R
Abstract excerpt
Using gene targeting in mice, we have undertaken a systematic mutational analysis of the homeobox-containing 5' HoxD genes. In particular, we have characterized the limb defects observed in mice with independent targeted disruptions of hoxd-12 and hoxd-13. Animals defective for hoxd-12 are viable...
Topics
- Animals
- Base Sequence
- Carpal Bones
- Crosses, Genetic
- Forelimb
- Gene Expression
- Gene Targeting
- Genes, Homeobox
- Heterozygote
- Homeodomain Proteins
- Humans
- Metacarpus
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Toes