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Article

A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.

Development (Cambridge, England) - 1 Apr 1996

Davis A P, Capecchi M R

Abstract excerpt

Using gene targeting in mice, we have undertaken a systematic mutational analysis of the homeobox-containing 5' HoxD genes. In particular, we have characterized the limb defects observed in mice with independent targeted disruptions of hoxd-12 and hoxd-13. Animals defective for hoxd-12 are viable, fertile, and appear outwardly normal yet have minor autopodal defects in the forelimb which include a reduction in...

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PMID: 8620844
DOI: 10.1242/dev.122.4.1175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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