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Article

Homodimerization antagonizes nuclear export of survivin.

Traffic (Copenhagen, Denmark) - 1 Nov 2007

Engelsma Dieuwke, Rodriguez Jose A, Fish Alexander, Giaccone Giuseppe, Fornerod Maarten

Abstract excerpt

Survivin plays separate roles during different phases of the cell cycle. In mitosis, Survivin is a key regulator of cell division, while in interphase, Survivin is able to protect cells from apoptosis. Survivin shuttles between nucleus and cytoplasm under the influence of one or more nuclear export signals (NESs). Paradoxically, our data show that Survivin poorly binds CRM1 in vitro because hydrophobic residues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17714426
DOI: 10.1111/j.1600-0854.2007.00629.x

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Homodimerization antagonizes nuclear export of survivin.PMID 17714426Read ↗

Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal.Semantic proximity Read ↗

Separating the anti-apoptotic and mitotic roles of survivin.Semantic proximity Read ↗

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.Semantic proximity Read ↗

The Survivin Isoform Survivin-3B is Cytoprotective and can Function as a Chromosomal Passenger Complex ProteinSemantic proximity Read ↗

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.Semantic proximity Read ↗

A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.Semantic proximity Read ↗

Survivin monomer plays an essential role in apoptosis regulation.Semantic proximity Read ↗

Using a Simple Cellular Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides.Semantic proximity Read ↗

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.Semantic proximity Read ↗

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.Semantic proximity Read ↗

Crystal Structure of Human Survivin Reveals a Bow Tie–Shaped Dimer with Two Unusual α-Helical ExtensionsSemantic proximity Read ↗

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.Semantic proximity Read ↗

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