Article
Survivin monomer plays an essential role in apoptosis regulation.
The Journal of biological chemistry - 1 Jul 2011
Pavlyukov Marat S, Antipova Nadezhda V, Balashova Maria V, Vinogradova Tatjana V, Kopantzev Evgenij P, Shakhparonov Mihail I
Abstract excerpt
Survivin was initially described as an inhibitor of apoptosis and attracted growing attention as one of the most tumor-specific genes in the human genome and a promising target for cancer therapy. Lately, it has been shown that survivin is a multifunctional protein that takes part in several crucial cell processes. At first, it was supposed that survivin functions only as a homodimer, but now data indicate that...
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