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Article

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.

The Journal of cell biology - 20 Oct 2008

Yue Zuojun, Carvalho Ana, Xu Zhenjie, Yuan Xuemei, Cardinale Stefano, Ribeiro Susana, Lai Fan, Ogawa Hiromi, Gudmundsdottir Elisabet, Gassmann Reto, Morrison Ciaran G, Ruchaud Sandrine, Earnshaw William C

Abstract excerpt

Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells. DT40 cells lacking Survivin die in interphase after failing to c...

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Identifiers

PMID: 18936249
DOI: 10.1083/jcb.200806118
PMCID: PMC2568024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18936249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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