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Article

Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal.

Traffic (Copenhagen, Denmark) - 1 Nov 2006

Stauber Roland H, Rabenhorst Uta, Rekik Alexander, Engels Knut, Bier Carolin, Knauer Shirley K

Abstract excerpt

Survivin appears to function as a regulator of cell division and as an apoptosis inhibitor in many species. Here, we characterized the nucleocytoplasmic transport of mouse survivin(140), and its splice variants survivin(121) and survivin(40). We show that the dynamic intracellular localization of survivin(140) is mediated by a Crm1-dependent nuclear export signal (NES) present also in survivin(121), but absent in...

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Source

Identifiers

PMID: 16984408
DOI: 10.1111/j.1600-0854.2006.00486.x

Genes

NES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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