Article
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.
Genes and immunity - 1 Oct 2007
Jeronimo S M B, Holst A K B, Jamieson S E, Francis R, Martins D R A, Bezerra F L, Ettinger N A, Nascimento E T, Monteiro G R, Lacerda H G, Miller E N, Cordell H J, Duggal P, Beaty T H, Blackwell J M, Wilson M E
Abstract excerpt
Visceral leishmaniasis (VL) caused by Leishmania chagasi is endemic to northeast Brazil. A positive delayed-type hypersensitivity skin test response (DTH+) is a marker for acquired resistance to disease, clusters in families and may be genetically controlled. Twenty-three single nucleotide polymorphisms (SNPs) were genotyped in the cytokine 5q23.3-q31.1 region IRF1-IL5-IL13-IL4-IL9-LECT2-TGFBI in 102 families...
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