Article
A Single Haplotype of IFNG Correlating With Low Circulating Levels of Interferon-γ Is Associated With Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 11 Jul 2020
da Silva George A V, Mesquita Tirza G, Souza Victor C, Junior José do Espírito Santo, Gomes de Souza Mara Lúcia, Talhari Anette Chrusciak, Talhari Sinésio, Naveca Felipe G, Ramasawmy Rajendranath
Abstract excerpt
BACKGROUND: Interferon-γ (IFN-γ) plays an important role in the control of Leishmania infection. Blockade of IFN-γ signaling in mice increases lesion size and parasite load. In endemic areas of Leishmaniasis, only a fraction of the population develop the disease. This suggest that host genetics may play a role in this response. We investigated whether single nucleotide polymorphisms (SNPs) in IFNG may be...
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