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Article

Genetic variations in the human immune system influence susceptibility to tegumentary leishmaniasis: a systematic review and meta-analysis.

Expert review of clinical immunology - 1 May 2021

Lera-Nonose Daniele Stéfanie Sara Lopes, De Oliveira Larissa Ferreira, Brustolin Aline, Santos Thais Silva, Oyama Jully, Ramos-Milaré Áquila Carolina Fernandes Herculano, Terron-Monich Mariana De Souza, Demarchi Izabel Galhardo, Neto Quirino Alves De Lima, Teixeira Jorge Juarez Vieira, Lonardoni Maria Valdrinez Campana

Abstract excerpt

OBJECTIVES: The outcomes of tegumentary leishmaniasis (TL) rely on a complex interaction between the host immune system and the parasite. This study assessed the influence of polymorphisms in immune-related genes on TL. METHODS: Web of Science, Scopus, PubMed, and Embase databases were searched systemically. The meta-analysis used a retrospective model in examining alleles, heterozygotes, and homozygotes. A...

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PMID: 33749481
DOI: 10.1080/1744666X.2021.1906650

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