Article
Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels.
PLoS neglected tropical diseases - 1 Jul 2025
Guerra Marcus Vinitius de Farias, de Souza Josué Lacerda, da Silva Lener Santos, Júnior José do Espírito Santo, de Mesquita Tirza Gabrielle Ramos, Queiroz Krys Layane Guimarães Duarte, da Silva George Allan Villarouco, Ogusku Mauricio Morishi, de Souza Mara Lúcia Gomes, Neto José Pereira de Moura, Sadahiro Aya, Ramasawmy Rajendranath
Abstract excerpt
BACKGROUND: The long non-coding RNA interferon gamma antisense-1 (IFNGAS-1) is essential for Th1 lineage specific expression of IFNG. IFN-γ is a key component cytokine in host immune response against intracellular pathogens like Leishmania. We investigated the association of two genetic variants of IFNGAS-1, rs4913269 and rs7134599, with susceptibility or protection to Leishmania guyanensis- induced cutaneous...
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