Article
Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan.
The Journal of infectious diseases - 15 Oct 2007
Jeronimo Selma M B, Duggal Priya, Ettinger Nicholas A, Nascimento Eliana T, Monteiro Gloria R, Cabral Angela P, Pontes Nubia N, Lacerda Henio G, Queiroz Paula V, Gomes Carlos E M, Pearson Richard D, Blackwell Jenefer M, Beaty Terri H, Wilson Mary E
Abstract excerpt
The protozoan Leishmania chagasi can cause disseminated, fatal visceral leishmaniasis (VL) or asymptomatic infection in humans. We hypothesized that host genetic factors contribute to this variable response to infection. A family study was performed in neighborhoods of endemicity for L. chagasi near Natal in northeastern Brazil. Study subjects were assessed for the presence of VL or asymptomatic infection, which...
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