Contrasting Genetic Effects Within STAT4 Define Susceptibility and Protection in Leishmania guyanensis Cutaneous Leishmaniasis.

doi:10.1093/infdis/jiag175

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Article

Contrasting Genetic Effects Within STAT4 Define Susceptibility and Protection in Leishmania guyanensis Cutaneous Leishmaniasis.

The Journal of infectious diseases - 23 Sept 2026

da Silva Lener Santos, de Souza Josué Lacerda, Menescal Lizandra Stephanny Fernandes, da Costa Torres Júlia, Gouveia Ana Vitoria Sena, Silva Eryck Gabriel Rodrigues, de Oliveira Micael Davi Lima, de Farias Guerra Marcus Vinitius, Ogusku Mauricio Morishi, Mombo Landry Erick, Boechat Antônio Luiz, de Moura Neto Jose Pereira, Lalwani Pritesh, Sadahiro Aya, Ramasawmy Rajendranath

Abstract excerpt

BACKGROUND: Leishmania guyanensis-associated cutaneous leishmaniasis (CL) is endemic in the Brazilian Amazonas. Despite similar exposure to the pathogen in endemic areas, only a subset of individuals develops disease, suggesting host-genetic control. STAT4 triggers interleukin 12 (IL-12)-dependent Th1 differentiation and interferon-γ (IFN-γ) production, essential for macrophage-mediated parasite clearance....

Read the complete abstract on PubMed

Topics

Humans
Leishmania guyanensis
STAT4 Transcription Factor
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Leishmaniasis, Cutaneous

Female

Case-Control Studies

Polymorphism, Single Nucleotide

Haplotypes

Brazil

Adult

Genotype

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 41905779
DOI: 10.1093/infdis/jiag175

Genes

STAT4
TNF

Provenance

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