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Parallel detection of SARS‐CoV ‐2 epitopes reveals dynamic immunodominance profiles of CD8 + T memory cells in convalescent COVID ‐19 donors

1 Jan 2022

Abstract excerpt

Abstract Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated protection are not well understood. The antigenic breadth and the immunodominance hierarchies of epitope‐specific CD8+ T cells remain largely unexplored and are essential for the development of next‐generation broad‐protective vaccines. This...

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PMID: 36254196
DOI: 10.1002/cti2.1423

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