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Article

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.

Science advances - 12 Apr 2024

Kristensen Nikolaj Pagh, Dionisio Edoardo, Bentzen Amalie Kai, Tamhane Tripti, Kemming Janine Sophie, Nos Grigorii, Voss Lasse Frank, Hansen Ulla Kring, Lauer Georg Michael, Hadrup Sine Reker

Abstract excerpt

CD8 T cells provide immunity to virus infection through recognition of epitopes presented by peptide major histocompatibility complexes (pMHCs). To establish a concise panel of widely recognized T cell epitopes from common viruses, we combined analysis of TCR down-regulation upon stimulation with epitope-specific enumeration based on barcode-labeled pMHC multimers. We assess CD8 T cell binding and reactivity for...

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Identifiers

PMID: 38608022
DOI: 10.1126/sciadv.adm8951
PMCID: PMC11014448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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