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Article

New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues.

British journal of pharmacology - 1 Oct 2007

Stitham J, Arehart E, Gleim S R, Li N, Douville K, Hwa J

Abstract excerpt

BACKGROUND AND PURPOSE: The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system. We hypothesized that significant insights could be gained into the structure and function of the hIP through mutagenesis of its energetically unfavourably located transmembrane charged...

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Identifiers

PMID: 17704830
DOI: 10.1038/sj.bjp.0707413
PMCID: PMC2050826

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Source receipt: pubmed, retrieved 7 Sept 2026.

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