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Article

In-silico characterization of deleterious non-synonymous SNPs in the human S1PR1 gene reveals structural instability and altered ligand affinity.

PloS one - 1 Jan 2026

Biswas Sangram, Sardar Dipankar, Hossain Md Arju, Hasnat Soharth, Ramjan Arif Hossain, Nazifa Ummah Kulsum, Zohora Fatema-Tuz, Esha Ishrat Jahan, Mondal Chandrika, Barik Abdul, Hoque M Nazmul

Abstract excerpt

S1PR1 is a G protein-coupled receptor that plays a key role in regulating lymphocyte trafficking, immune response, cardiovascular system function, cell proliferation and survival, tumor angiogenesis, and metastasis. It is also recognized as a pharmacotherapeutic target for the treatment of autoimmune diseases like relapsing multiple sclerosis and ulcerative colitis. This study aimed to identify deleterious...

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Identifiers

PMID: 41628231
DOI: 10.1371/journal.pone.0339370
PMCID: PMC12863678

Genes

S1PR1

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