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Article

High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.

PloS one - 1 Jan 2014

Bill Anke, Rosethorne Elizabeth M, Kent Toby C, Fawcett Lindsay, Burchell Lynn, van Diepen Michiel T, Marelli Anthony, Batalov Sergey, Miraglia Loren, Orth Anthony P, Renaud Nicole A, Charlton Steven J, Gosling Martin, Gaither L Alex, Groot-Kormelink Paul J

Abstract excerpt

The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numerous cardiovascular abnormalities, including myocardial infarction, hypertension, thrombosis and atherosclerosis. Genomic sequencing has discovered several genetic...

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Identifiers

PMID: 24886841
DOI: 10.1371/journal.pone.0097973
PMCID: PMC4041722

Genes

PTGIR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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