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Article

Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism.

The Journal of biological chemistry - 3 May 2002

Stitham Jeremiah, Stojanovic Aleksandar, Hwa John

Abstract excerpt

The human prostacyclin receptor (hIP) is a seven transmembrane-spanning G-protein-coupled receptor that plays an important role in vascular homeostasis. Recent genetic analyses (SNP database, NCBI) have revealed the first two polymorphisms within the coding sequence, V25M and R212H. Here we present structure-function characterizations of these polymorphisms at physiological pH (7.4) and at an acidic pH (6.8) that...

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Source

Identifiers

PMID: 11854299
DOI: 10.1074/jbc.M201187200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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