A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.

doi:10.1161/HYPERTENSIONAHA.111.176180

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Article

A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2011

Stokes Leanne, Scurrah Katrina, Ellis Justine A, Cromer Brett A, Skarratt Kristen K, Gu Ben J, Harrap Stephen B, Wiley James S

Abstract excerpt

The P2X4 receptor is involved in endothelium-dependent changes in large arterial tone in response to shear stress and is, therefore, potentially relevant to arterial compliance and pulse pressure. Four identified nonsynonymous polymorphisms in P2RX4 were reproduced in recombinantly expressed human P2X4. Electrophysiological studies showed that one of these, the Tyr315>Cys mutation (rs28360472), significantly...

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PMID: 22068874
DOI: 10.1161/HYPERTENSIONAHA.111.176180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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