Article
The L84F polymorphism in the O6-Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers.
Pharmacogenetics and genomics - 1 Sept 2007
Hill Courtney E, Wickliffe Jeffrey K, Guerin Adele T, Kinslow Carla J, Wolfe Kevin J, Ammenheuser Marinel M, Abdel-Rahman Sherif Z
Abstract excerpt
OBJECTIVES: O-methylguanine-DNA-methyltransferase (MGMT) is a crucial DNA repair protein that removes DNA adducts formed by alkylating mutagens. Several coding single nucleotide polymorphisms (cSNPs) in the MGMT gene have been reported. Their biological significance, however, is not known. METHODS: We used a newly modified cloning HPRT mutant lymphocyte assay to test the hypothesis that inheritance of the L84F...
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