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Article

Lung cancer risk and variation in MGMT activity and sequence.

DNA repair - 1 Aug 2007

Povey Andrew C, Margison Geoffrey P, Santibáñez-Koref Mauro F

Abstract excerpt

O(6)-Alkylguanine-DNA alkyltransferase (MGMT) repairs DNA adducts that result from alkylation at the O(6) position of guanine. These lesions are mutagenic and toxic and can be produced by a variety of agents including the tobacco-specific nitrosamines, carcinogens present in cigarette smoke. Here, we review some of our work in the context of inter-individual differences in MGMT expression and their potential...

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Share to Alkylating Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17569600
DOI: 10.1016/j.dnarep.2007.03.022

Genes

MGMT

Provenance

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Related research

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Lung cancer risk and variation in MGMT activity and sequence.PMID 17569600Read ↗

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