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Article

Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis.

Mutagenesis - 1 Jan 2010

Zhong Yu, Huang Yongsheng, Huang Yan, Zhang Tianbao, Ma Chengying, Zhang Shuyong, Fan Weiwei, Chen Hongyan, Qian Ji, Lu Daru

Abstract excerpt

O(6)-methylguanine-DNA methyltransferase is one of the rare proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. Its two common single-nucleotide polymorphisms, Leu84Phe and Ile143Val, had previously been identified to contribute to susceptibility of cancer. However, there are conflicting results in studies on the association of the two polymorphisms with cancer....

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Identifiers

PMID: 19892775
DOI: 10.1093/mutage/gep050

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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