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Article

Genetic association and functional studies of major polymorphic variants of MGMT.

DNA repair - 1 Aug 2007

Bugni James M, Han Jiali, Tsai Miaw-sheue, Hunter David J, Samson Leona D

Abstract excerpt

The DNA repair protein, O(6)-methylguanine DNA-methyltransferase (MGMT) prevents mutations and cell death that result from aberrant alkylation of DNA. The polymorphic variants Leu84Phe, Ile143Val, and Lys178Arg are frequent in the human population. We review here studies of these and other MGMT polymorphisms and their association with risk for lung, breast, colorectal and endometrial cancer with a consideration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17569599
DOI: 10.1016/j.dnarep.2007.03.023

Genes

MGMT

Provenance

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Genetic association and functional studies of major polymorphic variants of MGMT.PMID 17569599Read ↗

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