Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum.

Molecular biology of the cell - 1 Oct 2007

Chen Ying, McQuade Kyle J, Guan Xiao-Juan, Thomason Peter A, Wert Michael S, Stock Jeffry B, Cox Edward C

Abstract excerpt

Members of the Ras superfamily of small GTPases and the heterotrimeric G protein gamma subunit are methylated on their carboxy-terminal cysteine residues by isoprenylcysteine methyltransferase. In Dictyostelium discoideum, small GTPase methylation occurs seconds after stimulation of starving cells by cAMP and returns quickly to basal levels, suggesting an important role in cAMP-dependent signaling. Deleting the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell-Free System
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dictyostelium

Share to Food Deprivation

Share to Heterotrimeric GTP-Binding Proteins

Share to Methylation

Share to Protein Methyltransferases

Share to Receptors, Cyclic AMP

Source

Open in PubMed Open full text

Identifiers

PMID: 17699599
DOI: 10.1091/mbc.e06-11-1006
PMCID: PMC1995708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum.PMID 17699599Read ↗

A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.Semantic proximity Read ↗

A novel Dictyostelium RasGEF required for chemotaxis and development.Semantic proximity Read ↗

A novel Dictyostelium discoideum gene required for cAMP-dependent cell aggregation.Semantic proximity Read ↗

Multiple roles for cAMP-dependent protein kinase during Dictyostelium development.Semantic proximity Read ↗

A role for cAMP-dependent protein kinase A in early Dictyostelium development.Semantic proximity Read ↗

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.Semantic proximity Read ↗

G alpha 3 regulates the cAMP signaling system in Dictyostelium.Semantic proximity Read ↗

Null mutations of the Dictyostelium cyclic nucleotide phosphodiesterase gene block chemotactic cell movement in developing aggregates.Semantic proximity Read ↗

Assessment of development and chemotaxis in Dictyostelium discoideum mutants.Semantic proximity Read ↗

Loss of Copine D Leads to Ras Activation in Dictyostelium discoideum.Semantic proximity Read ↗

Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.Semantic proximity Read ↗

Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.