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Article

Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.

Development (Cambridge, England) - 1 Sept 2001

Li G, Foote C, Alexander S, Alexander H

Abstract excerpt

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes...

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Identifiers

PMID: 11566853
DOI: 10.1242/dev.128.18.3473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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