Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Copine D Leads to Ras Activation in Dictyostelium discoideum.

Cells - 31 Jul 2026

Morrison Cody T, Damer-Daigle Sela K, Maillette Allison G, Damer Cynthia K

Abstract excerpt

Copines are a family of calcium-dependent phospholipid-binding proteins conserved across numerous eukaryotes. The expression of multiple copine genes is dysregulated in several human cancers, yet their molecular functions remain poorly understood. We are investigating copine genes (cpnA-cpnF) in the amoeba Dictyostelium discoideum, a well-established model for studying conserved signaling pathways that regulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Proliferation
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Dictyostelium

Share to Phosphatidylinositol 3-Kinases

Share to Protozoan Proteins

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42587796
DOI: 10.3390/cells15151389
PMCID: PMC13465345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Copine D Leads to Ras Activation in Dictyostelium discoideum.PMID 42587796Read ↗

Loss of Copine D Leads to Ras Activation in <i>Dictyostelium discoideum</i>Semantic proximity Read ↗

Assessment of development and chemotaxis in Dictyostelium discoideum mutants.Semantic proximity Read ↗

A novel Dictyostelium discoideum gene required for cAMP-dependent cell aggregation.Semantic proximity Read ↗

Phosphatidylserine exposure promotes increased adhesion in Dictyostelium Copine A mutants.Semantic proximity Read ↗

Microarray phenotyping places cyclase associated protein CAP at the crossroad of signaling pathways reorganizing the actin cytoskeleton in Dictyostelium.Semantic proximity Read ↗

A novel Dictyostelium RasGEF required for chemotaxis and development.Semantic proximity Read ↗

Evolution of multicellularity in Dictyostelia.Semantic proximity Read ↗

DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells.Semantic proximity Read ↗

Dictyostelium discoideum as a Model for Investigating Neurodegenerative DiseasesSemantic proximity Read ↗

A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.Semantic proximity Read ↗

DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum.Semantic proximity Read ↗

Characterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.