Article
Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains.
Physiological genomics - 14 Nov 2007
Ferraro Thomas N, Smith George G, Schwebel Candice L, Lohoff Falk W, Furlong Patrick, Berrettini Wade H, Buono Russell J
Abstract excerpt
Multiple quantitative trait locus (QTL) mapping studies designed to localize seizure susceptibility genes in C57BL/6 (B6, seizure resistant) and DBA/2 (D2, seizure susceptible) mice have detected a significant effect originating from midchromosome 5. To confirm the presence and refine the position of the chromosome 5 QTL for maximal electroshock seizure threshold (MEST), reciprocal congenic strains between B6 and...
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