Article
Genome-tagged mice (GTM): two sets of genome-wide congenic strains.
Genomics - 15 May 2001
Iakoubova O A, Olsson C L, Dains K M, Ross D A, Andalibi A, Lau K, Choi J, Kalcheva I, Cunanan M, Louie J, Nimon V, Machrus M, Bentley L G, Beauheim C, Silvey S, Cavalcoli J, Lusis A J, West D B
Abstract excerpt
An important approach for understanding complex disease risk using the mouse is to map and ultimately identify the genes conferring risk. Genes contributing to complex traits can be mapped to chromosomal regions using genome scans of large mouse crosses. Congenic strains can then be developed to fine-map a trait and to ascertain the magnitude of the genotype effect in a chromosomal region. Congenic strains are...
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