Article
Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice.
Physiological genomics - 1 Sept 2010
Ferraro T N, Smith G G, Schwebel C L, Doyle G A, Ruiz S E, Oleynick J U, Lohoff F W, Berrettini W H, Buono R J
Abstract excerpt
To confirm seizure susceptibility (SZS) quantitative trait loci (QTLs) on chromosome (chr) 15 identified previously using C57BL/6J (B6) and DBA/2J (D2) mice and to refine their genomic map position, we studied a set of three congenic strains in which overlapping segments of chr 15 from D2 were transferred onto the B6 background. We measured thresholds for generalized electroshock seizure (GEST) and maximal...
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