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Article

Global diversity and evidence for coevolution of KIR and HLA.

Nature genetics - 1 Sept 2007

Single Richard M, Martin Maureen P, Gao Xiaojiang, Meyer Diogo, Yeager Meredith, Kidd Judith R, Kidd Kenneth K, Carrington Mary

Abstract excerpt

The killer immunoglobulin-like receptor (KIR) gene cluster shows extensive genetic diversity, as do the HLA class I loci, which encode ligands for KIR molecules. We genotyped 1,642 individuals from 30 geographically distinct populations to examine population-level evidence for coevolution of these two functionally related but unlinked gene clusters. We observed strong negative correlations between the presence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17694058
DOI: 10.1038/ng2077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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