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Article

Human KIR repertoires: shaped by genetic diversity and evolution.

Immunological reviews - 1 Sept 2015

Manser Angela R, Weinhold Sandra, Uhrberg Markus

Abstract excerpt

Killer cell immunoglobulin-like receptors (KIRs) on natural killer (NK) cells are crucially involved in the control of cancer development and virus infection by probing cells for proper expression of HLA class I. The clonally distributed expression of KIRs leads to great combinatorial diversity that develops in the presence of the evolutionary older CD94/NKG2A receptor to create highly stochastic but tolerant...

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Share to Evolution, Molecular
Share to Genetic Variation
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

Share to Models, Genetic

Share to Models, Immunological

Share to Receptors, KIR

Source

Identifiers

PMID: 26284478
DOI: 10.1111/imr.12316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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