Article
The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates.
Frontiers in immunology - 1 Jan 2020
Bruijnesteijn Jesse, de Groot Natasja G, Bontrop Ronald E
Abstract excerpt
The activity and function of natural killer (NK) cells are modulated through the interactions of multiple receptor families, of which some recognize MHC class I molecules. The high level of MHC class I polymorphism requires their ligands either to interact with conserved epitopes, as is utilized by the NKG2A receptor family, or to co-evolve with the MHC class I allelic variation, which task is taken up by the...
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