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Article

Global patterns of KIR genotype diversity reflect human migration and regional differences.

Frontiers in immunology - 1 Jan 2026

Barani Shaghik, Guethlein Lisbeth, Middleton Derek, Gonzalez-Galarza Faviel F, Rajalingam Raja

Abstract excerpt

Background: Killer-cell immunoglobulin-like receptors (KIR) are highly polymorphic receptors expressed by natural killer (NK) cells that regulate immune responses through interactions with HLA class I ligands. Variation in KIR gene content influences immunity, reproduction, transplantation outcomes, and susceptibility to disease, yet global patterns of KIR genotype diversity remain incompletely characterized....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42656673
DOI: 10.3389/fimmu.2026.1902165
PMCID: PMC13506890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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