Article
Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region.
Molecular biology and evolution - 7 Jan 2022
Vargas Luciana de Brito, Beltrame Marcia H, Ho Brenda, Marin Wesley M, Dandekar Ravi, Montero-Martín Gonzalo, Fernández-Viña Marcelo A, Hurtado A Magdalena, Hill Kim R, Tsuneto Luiza T, Hutz Mara H, Salzano Francisco M, Petzl-Erler Maria Luiza, Hollenbach Jill A, Augusto Danillo G
Abstract excerpt
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells. KIR genes are encoded by a rapidly evolving gene family on chromosome 19 and present an unusual variation of presence and absence of genes and high allelic diversity. Although many studies have associated KIR polymorphism with...
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