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Article

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.

Frontiers in immunology - 1 Jan 2020

Alicata Claudia, Ashouri Elham, Nemat-Gorgani Neda, Guethlein Lisbeth A, Marin Wesley M, Tao Sudan, Moretta Lorenzo, Hollenbach Jill A, Trowsdale John, Traherne James A, Ghaderi Abbas, Parham Peter, Norman Paul J

Abstract excerpt

Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell function, KIR polymorphism associates with infection control and multiple autoimmune and pregnancy syndromes. Here we analyze KIR diversity of 241 individuals from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32300348
DOI: 10.3389/fimmu.2020.00556
PMCID: PMC7142237

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