Article
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.
Genome research - 1 May 2009
Norman Paul J, Abi-Rached Laurent, Gendzekhadze Ketevan, Hammond John A, Moesta Achim K, Sharma Deepti, Graef Thorsten, McQueen Karina L, Guethlein Lisbeth A, Carrington Christine V F, Chandanayingyong Dasdayanee, Chang Yih-Hsin, Crespí Catalina, Saruhan-Direskeneli Güher, Hameed Kamran, Kamkamidze Giorgi, Koram Kwadwo A, Layrisse Zulay, Matamoros Nuria, Milà Joan, Park Myoung Hee, Pitchappan Ramasamy M, Ramdath D Dan, Shiau Ming-Yuh, Stephens Henry A F, Struik Siske, Tyan Dolly, Verity David H, Vaughan Robert W, Davis Ronald W, Fraser Patricia A, Riley Eleanor M, Ronaghi Mostafa, Parham Peter
Abstract excerpt
Natural killer (NK) cells contribute to the essential functions of innate immunity and reproduction. Various genes encode NK cell receptors that recognize the major histocompatibility complex (MHC) Class I molecules expressed by other cells. For primate NK cells, the killer-cell immunoglobulin-like receptors (KIR) are a variable and rapidly evolving family of MHC Class I receptors. Studied here is KIR3DL1/S1,...
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