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Article

Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.

PloS one - 1 Jan 2012

Vierra-Green Cynthia, Roe David, Hou Lihua, Hurley Carolyn Katovich, Rajalingam Raja, Reed Elaine, Lebedeva Tatiana, Yu Neng, Stewart Mary, Noreen Harriet, Hollenbach Jill A, Guethlein Lisbeth A, Wang Tao, Spellman Stephen, Maiers Martin

Abstract excerpt

The immune responses of natural killer cells are regulated, in part, by killer cell immunoglobulin-like receptors (KIR). The 16 closely-related genes in the KIR gene system have been diversified by gene duplication and unequal crossing over, thereby generating haplotypes with variation in gene copy number. Allelic variation also contributes to diversity within the complex. In this study, we estimated allele-level...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23139747
DOI: 10.1371/journal.pone.0047491
PMCID: PMC3489906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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