Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genetic and evolutionary balances in human NK cell receptor diversity.

Seminars in immunology - 1 Dec 2008

Parham Peter

Abstract excerpt

In primates and cattle two ancient killer-cell immunoglobulin-like receptor (KIR) lineages independently evolved to become diverse NK cell receptors. In mice, KIR genes were sidelined to the X chromosome, a possible consequence of pathogen-mediated selection on the receptor for IgA-Fc. In humans, KIR uniquely form two omnipresent haplotype groups (A and B), postulated here to play complementary and necessary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Evolution, Molecular
Share to Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Fc

Share to Receptors, KIR

Share to Receptors, KIR3DL1

Share to Receptors, Natural Killer Cell

Share to Reproduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19036608
DOI: 10.1016/j.smim.2008.10.002
PMCID: PMC3205964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic and evolutionary balances in human NK cell receptor diversity.PMID 19036608Read ↗

Human KIR repertoires: shaped by genetic diversity and evolution.Semantic proximity Read ↗

Variable NK cell receptors exemplified by human KIR3DL1/S1.Semantic proximity Read ↗

KIR: diverse, rapidly evolving receptors of innate and adaptive immunity.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor diversity: balancing signals in the natural killer cell response.Semantic proximity Read ↗

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.Semantic proximity Read ↗

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations.Semantic proximity Read ↗

Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family.Semantic proximity Read ↗

Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.Semantic proximity Read ↗

Overview of the killer cell immunoglobulin-like receptor system.Semantic proximity Read ↗

The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates.Semantic proximity Read ↗

Co-evolution of MHC class I and variable NK cell receptors in placental mammals.Semantic proximity Read ↗

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.