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Article

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Nature - 20 Sept 2007

Travis Mark A, Reizis Boris, Melton Andrew C, Masteller Emma, Tang Qizhi, Proctor John M, Wang Yanli, Bernstein Xin, Huang Xiaozhu, Reichardt Louis F, Bluestone Jeffrey A, Sheppard Dean

Abstract excerpt

The cytokine transforming growth factor-beta (TGF-beta) is an important negative regulator of adaptive immunity. TGF-beta is secreted by cells as an inactive precursor that must be activated to exert biological effects, but the mechanisms that regulate TGF-beta activation and function in the immu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17694047
DOI: 10.1038/nature06110
PMCID: PMC2670239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-17694047-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.PMID 17694047Read ↗

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