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Article

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Nature - 20 Sept 2007

Travis Mark A, Reizis Boris, Melton Andrew C, Masteller Emma, Tang Qizhi, Proctor John M, Wang Yanli, Bernstein Xin, Huang Xiaozhu, Reichardt Louis F, Bluestone Jeffrey A, Sheppard Dean

Abstract excerpt

The cytokine transforming growth factor-beta (TGF-beta) is an important negative regulator of adaptive immunity. TGF-beta is secreted by cells as an inactive precursor that must be activated to exert biological effects, but the mechanisms that regulate TGF-beta activation and function in the immune system are poorly understood. Here we show that conditional loss of the TGF-beta-activating integrin alpha(v)beta8...

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Identifiers

PMID: 17694047
DOI: 10.1038/nature06110
PMCID: PMC2670239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.PMID 17694047Read ↗

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