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Article

Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice.

The Journal of cell biology - 12 Mar 2007

Yang Zhiwei, Mu Zhenyu, Dabovic Branka, Jurukovski Vladimir, Yu Dawen, Sung Joanne, Xiong Xiaozhong, Munger John S

Abstract excerpt

The multifunctional cytokine transforming growth factor (TGF) beta1 is secreted in a latent complex with its processed propeptide (latency-associated peptide [LAP]). TGFbeta1 must be functionally released from this complex before it can engage TGFbeta receptors. One mechanism of latent TGFbeta1 activation involves interaction of the integrins alpha v beta6 and alpha v beta8 with an RGD sequence in LAP; other...

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Identifiers

PMID: 17353357
DOI: 10.1083/jcb.200611044
PMCID: PMC2064053

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Source receipt: pubmed, retrieved 7 Sept 2026.

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