Article
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014
Wang Li, Le Mercier Isabelle, Putra Juan, Chen Wenna, Liu Jun, Schenk Austin D, Nowak Elizabeth C, Suriawinata Arief A, Li Jiannan, Noelle Randolph J
Abstract excerpt
V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous studies using a VISTA-neutralizing monoclonal antibody show that VISTA blockade enhances T-cell activation. The current study describes a comprehensive characterization of mice in which the gene for VISTA has been deleted. Despite the apparent normal...
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