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Article

Inflammasome-Independent NLRP3 Augments TGF-β Signaling in Kidney Epithelium

22 Dec 2012

Abstract excerpt

Tubulointerstitial inflammation and fibrosis are strongly associated with the outcome of chronic kidney disease. We recently demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal inflammation, injury, and fibrosis following unilateral ureteric obstruction in mice. NLRP3 expression in renal tubular epithelial cells (TECs) was found to be an important component of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23264657
DOI: 10.4049/jimmunol.1201959

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