Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping.

Abstract excerpt

Tagging single nucleotide polymorphisms (tSNPs) are commonly used to capture genetic diversity cost-effectively. It is important that the efficacy of tSNPs is correctly estimated, otherwise coverage may be inadequate and studies underpowered. Using data simulated under a coalescent model, we show that insufficient sample size can lead to overestimation of tSNP efficacy. Quantifying this we find that even when...

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