Article
Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping.
Genetic epidemiology - 1 Jan 2008
Iles Mark M
Abstract excerpt
Tagging single nucleotide polymorphisms (tSNPs) are commonly used to capture genetic diversity cost-effectively. It is important that the efficacy of tSNPs is correctly estimated, otherwise coverage may be inadequate and studies underpowered. Using data simulated under a coalescent model, we show...
Topics
- Chromosome Mapping
- Computer Simulation
- Genetic Markers
- Genetic Predisposition to Disease
- Genome, Human
- Haplotypes
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Sample Size