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Article

Correcting coalescent analyses for panel-based SNP ascertainment.

Genetics - 1 Apr 2013

McGill James R, Walkup Elizabeth A, Kuhner Mary K

Abstract excerpt

Single-nucleotide polymorphism (SNP) data are routinely obtained by sequencing a region of interest in a small panel, constructing a chip with probes specific to sites found to vary in the panel, and using the chip to assay subsequent samples. The size of the chip is often reduced by removing low-frequency alleles from the set of SNPs. Using coalescent estimation of the scaled population size parameter, Θ, as a...

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Identifiers

PMID: 23335334
DOI: 10.1534/genetics.112.146738
PMCID: PMC3606096

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Source receipt: pubmed, retrieved 7 Sept 2026.

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