The impact of missing and erroneous genotypes on tagging SNP selection and power of subsequent association tests.

doi:10.1159/000092141

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Article

The impact of missing and erroneous genotypes on tagging SNP selection and power of subsequent association tests.

Human heredity - 1 Jan 2006

Liu Wenlei, Zhao Wei, Chase Gary A

Abstract excerpt

OBJECTIVE: Single nucleotide polymorphisms (SNPs) serve as effective markers for localizing disease susceptibility genes, but current genotyping technologies are inadequate for genotyping all available SNP markers in a typical linkage/association study. Much attention has recently been paid to me...

Topics

Algorithms
Aromatase
Chromosome Mapping
Computer Simulation
Gene Frequency
Genetic Linkage
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Models, Statistical
Polymorphism, Single Nucleotide
Risk
Selection, Genetic

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